Colgate<sup>®</sup> PerioGard<sup>®</sup> (Chlorhexidine Gluconate Oral Rinse, 0.12%) Mouthwash (Rx only)

Colgate® PerioGard® (Chlorhexidine Gluconate Oral Rinse, 0.12%) Mouthwash (Rx only)

A broad-spectrum, antimicrobial oral rinse that has been proven safe and effective for treating gingivitis.


Active ingredients

0.12% Chlorhexidine Gluconate

Inactive ingredients

Water, Glycerin, Sorbitol, PEG-40, Hydrogenated Castor Oil, Flavor, Citric acid, CI42051.

*Does Not Contain Ethyl Alcohol.

Mode of Action

Chlorhexidine gluconate provides antimicrobial activity during oral rinsing. The clinical significance of 0.12% chlorhexidine gluconate oral rinse's antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54-97% through 6 months' use. Use of a chlorhexidine gluconate oral rinse in a 6-month clinical study did not result in any significant changes in bacterial resistance, overgrowth of potentially opportunistic organisms, or other adverse changes in the oral microbial ecosystem. Three months after chlorhexidine gluconate use was discontinued, the number of bacteria in plaque had returned to baseline levels and the resistance of plaque bacteria to chlorhexidine gluconate was equal to that at baseline.

Proof of Efficacy

Clinical effects of a 0.12% chlorhexidine rinse as an adjunct to scaling and root planing.

Beiswanger BB, Mallat ME, Jackson RD, Mau MS, Farah CF, Bosma ML, Bollmer BW, Hancock EB.

Gingival healing following scaling and root planing in subjects using a chlorhexidine rinse (0.12%) was significantly better than subjects using the placebo rinse, as evidenced by less gingivitis (29%), fewer GI bleeding sites (48%), and less plaque (54%).