Colgate<sup>®</sup> Sensitive Pro-Relief<sup>™</sup> Toothpaste with Pro-Argin<sup>™</sup> Technology

Colgate® Sensitive Pro-Relief Toothpaste with Pro-Argin Technology

Delivers both instant* and lasting hypersensitivity relief together with the recommended fluoride level for caries prevention (1450ppm F).


Active ingredients

Arginine 8% w/w, Sodium Monofluorophosphate 1.1% w/w (1450ppm F)

Inactive ingredients

Calcium Carbonate, Water, Sorbitol, Arginine Bicarbonate, Sodium Lauryl Sulfate, Flavor, Sodium Monofluorophosphate, Cellulose Gum, Sodium Bicarbonate, Potassium Acesulfame, Sodium Silicate, Xanthan Gum, Sucralose, CI 77891

Mode of Action

The Pro-Argin technology plugs and seals open dentine tubules with a calcium-rich mineral layer.

Proof of Efficacy

Clinical efficacy of Colgate® Sensitive Pro-Relief toothpaste

F Ayad, N Ayad, YP Zhang, W DeVizio, D Cummins, and LR Mateo


When used over a period of 8 weeks, the novel toothpaste containing arginine and MFP in a calcium carbonate base significantly reduced dentine hypersensitivity (p < 0.05) in response to both the tactile and air blast stimuli. Compared to the commercial toothpaste with 2% potassium ion and NaF, the arginine containing toothpaste was significantly (p <0.05) more effective in reducing hypersensitivity scores after 2, 4, and 8 weeks of use (16.2%, 22.4%, and 21.4% for tactile stimuli; 16.2%, 29.2% and 63.4% for air blast stimuli).


A new toothpaste with 8% arginine, calcium carbonate and 1450 ppm fluoride (MFP) provided significantly (p < 0.05) greater dentine hypersensitivity relief after 2, 4, and 8 weeks of use than a desensitising toothpaste containing 2% potassium ion and 1450 ppm fluoride (NaF).